| Product Name | Sincalide |
| Synonyms | CCK-8 (sulfated), Cholecystokinin octapeptide, Kinevac, SQ-19844 |
| CAS Number | 25126-32-3 |
| Sequence (3-Letter) | H-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH₂ (Tyr O-sulfated; C-terminal amide) |
| Sequence (1-Letter) | D-Y(SO3H)-MGWMDF-NH₂ |
| Molecular Formula | C₄₉H₆₂N₁₀O₁₆S₃ |
| Molecular Weight | 1143.3 |
| Category | Drug Peptide – Cholecystokinin Octapeptide (CCK Receptor Agonist) |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Acetate / ammonium (salt form per specification) |
| Peptide Content | ≥80% (per specification) |
| Solubility | Soluble in water |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – g (research quantities; larger scale on enquiry) |
| QC Documentation | COA, HPLC, MS identity, tyrosine-sulfation confirmation (additional API/regulatory documentation on request) |
| Usage | For research and pharmaceutical development use, and as a reference standard or active pharmaceutical ingredient for manufacturing. Not for human or veterinary use; not for sale to patients. Any therapeutic use is subject to applicable regulatory approval. |
Sincalide is a synthetic eight-residue peptide that matches the C-terminal end of the natural hormone cholecystokinin, often called CCK-8, and is known as a medicine under the brand name Kinevac (CAS 25126-32-3). Its sequence is Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2, with a sulfate group on the tyrosine and an amide at the C-terminus. The sulfate group is needed for full activity. We supply it as a white powder for research and pharmaceutical development.
Sincalide copies the action of cholecystokinin. It binds CCK receptors and makes the muscle of the gallbladder contract, which squeezes bile out of the gallbladder, and it also stimulates the pancreas to release its secretions. These are the same responses the body's own CCK produces after a meal.
Sincalide is used mainly as a diagnostic agent: to make the gallbladder contract during imaging tests, to help collect bile or pancreatic samples, and to speed the passage of a contrast meal through the gut. This is background information only; the material we supply is for research and pharmaceutical manufacturing use, and is not for human or veterinary use and not for sale to patients.
We supply Sincalide with a certificate of analysis, HPLC purity data, and mass-spec identity confirmation, and we can confirm the tyrosine sulfation. Additional documentation for API and regulatory work is available on request, and salt form and purity can be set to your specification.
Yes. We manufacture Sincalide in-house and supply from research quantities up to larger batches. Because the tyrosine sulfation has to be made and kept intact, it is a demanding synthesis, and we can discuss the right approach for your scale. Contact us with your required purity and quantity for a quote.
Sincalide is a synthetic octapeptide that matches the C-terminal end of the natural hormone cholecystokinin (CCK), commonly known as CCK-8. It is known as a medicine under the brand name Kinevac and is used mainly as a diagnostic agent. We supply it as a raw material for research and pharmaceutical development.
Sincalide is an eight-residue peptide, Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2, identical to the last eight amino acids of cholecystokinin. The tyrosine carries a sulfate group and the C-terminus is an amide; the sulfate in particular is needed for the peptide to show full CCK activity, and it is more potent than the unsulfated form. Its CAS number is 25126-32-3, its molecular formula is C49H62N10O16S3, and its molecular weight is about 1143.
Sincalide reproduces the action of cholecystokinin. It binds CCK receptors and causes the smooth muscle of the gallbladder to contract, emptying bile from the gallbladder, and it stimulates the pancreas to release digestive secretions. These are the same responses that the body's own CCK produces after a meal, which is why sincalide is useful for probing gallbladder and pancreatic function.
Sincalide is used mainly as a diagnostic agent: to stimulate gallbladder contraction during imaging studies, to help obtain bile or pancreatic samples for analysis, and to accelerate the passage of a contrast meal through the bowel. This information is provided as scientific and reference background only. The material supplied by SynPeptide is intended for research and pharmaceutical manufacturing, is not for human or veterinary use, and is not for sale to patients; any diagnostic or therapeutic use is subject to applicable regulatory approval.
Because sincalide depends on a correctly placed tyrosine sulfate group, careful synthesis and analysis matter. We supply it with a certificate of analysis, HPLC purity data, mass-spectrometry identity confirmation, and confirmation of the tyrosine sulfation, with further documentation available to support active pharmaceutical ingredient and regulatory work, and purity and salt form set to your specification.
We manufacture Sincalide by solid-phase synthesis, including the tyrosine sulfation and C-terminal amide, and supply it from research quantities through to larger batches. For related capabilities, see drug peptides, custom peptide synthesis, peptide modification, and our peptide CDMO services. Material is supplied for research and pharmaceutical manufacturing use only.
