| Product Name | Nonapeptide-1 (Melanostatine-5) |
| Synonyms | Melanostatine-5, Melanostatine, Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH₂ |
| CAS Number | 158563-45-2 |
| Sequence (3-Letter) | Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH₂ |
| Sequence (1-Letter) | MPfRwFKPV-NH₂ (f = D-Phe, w = D-Trp) |
| Molecular Formula | C₆₁H₈₇N₁₅O₉S |
| Molecular Weight | 1206.52 |
| Category | Cosmetic Peptide |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white powder |
| Counter Ion | Acetate (TFA-free available on request) |
| Peptide Content | ≥90% |
| Solubility | Soluble in water |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – kg |
| QC Documentation | COA, HPLC, MS (included with every order) |
| Usage | For cosmetic formulation and research use only. Supplied as a raw material; finished-product efficacy and safety claims are the formulator's responsibility. Not a drug; not for direct use without formulation. |
Nonapeptide-1 is a cosmetic skin-brightening peptide, also known by the trade name Melanostatine-5 (CAS 158563-45-2). It is a nine-amino-acid biomimetic peptide modeled on a fragment of alpha-melanocyte-stimulating hormone, with two D-amino acids that make it stable. It is supplied as a white powder for skincare and research.
Nonapeptide-1 is used in brightening and spot-correcting products to help even out skin tone and reduce the look of dark spots and uneven pigmentation. Suppliers describe it as an alpha-MSH antagonist that limits melanin formation. Any efficacy claim on a finished product is the formulator's responsibility.
Skin colour comes from melanin made by melanocytes when alpha-MSH activates the MC1 receptor and switches on tyrosinase. Nonapeptide-1 competes with alpha-MSH at that receptor, which is reported to reduce tyrosinase activation and melanin synthesis, helping limit the look of dark spots and uneven tone. This is a topical cosmetic effect on the appearance of the skin.
Nonapeptide-1 is water-soluble and is added to leave-on brightening serums, creams, and spot-correcting products at low levels. It pairs well with other brightening ingredients. We can advise on use levels for your product.
Yes. We manufacture Nonapeptide-1 in-house and supply from milligrams to kilograms, with COA, HPLC, and MS included. Contact us with your required purity and quantity for a quote.
Nonapeptide-1 is a synthetic peptide used in skincare to brighten the complexion and even out skin tone. It is sold under the trade name Melanostatine-5 and is one of the better-known peptides aimed at the look of dark spots and uneven pigmentation.
Nonapeptide-1 is a nine-amino-acid peptide with the sequence Met-Pro-D-Phe-Arg-D-Trp-Phe-Lys-Pro-Val-NH2. It is a biomimetic peptide modeled on a fragment of alpha-melanocyte-stimulating hormone, and it includes two D-amino acids, D-phenylalanine and D-tryptophan, which make it more resistant to breakdown. Its CAS number is 158563-45-2, its molecular formula is C61H87N15O9S, and its molecular weight is about 1206.5.
Skin colour comes from melanin, which melanocytes produce when alpha-melanocyte-stimulating hormone (alpha-MSH) binds the MC1 receptor and switches on the enzyme tyrosinase. Nonapeptide-1 is an antagonist of alpha-MSH: it competes for the MC1 receptor, which is reported to reduce tyrosinase activation and melanin synthesis. In a cosmetic product this is the rationale for using it to help even skin tone and soften the look of dark spots. The effect is on the appearance of the skin.
Nonapeptide-1 is water-soluble and is added at low levels to leave-on brightening serums, creams, and spot-correcting products. It is often paired with other brightening ingredients in tone-evening formulas. As with all cosmetic actives, any claim made on the finished product is the responsibility of the formulator.
Nonapeptide-1 is used at trace levels and is handled as a standard cosmetic raw material. Supplier studies report reduced melanin synthesis and an improvement in the look of uneven tone with regular use, but any claim on a finished product is the responsibility of the formulator, and finished products should be safety-assessed for their specific formula and use.
We manufacture Nonapeptide-1 by solid-phase synthesis, including the D-amino acid residues and the C-terminal amide, and supply it from milligram to kilogram scale with a COA, HPLC, and MS report. For related ingredients and the underlying chemistry, see cosmetic peptides, custom peptide synthesis, and peptide modification. This material is supplied for cosmetic formulation and research use and is not a drug.
