| Product Name | Lypressin (Lysine Vasopressin) |
| Synonyms | [Lys8]-Vasopressin; Lysipressin; LVP; 8-L-lysine vasopressin; Vasopressin (catalogue name) |
| CAS Number | 50-57-7 |
| Sequence (3-Letter) | H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 |
| Sequence (1-Letter) | CYFQNCPKG-NH2 (9 residues; C-terminal amide) |
| Disulfide Bridge | Cys1–Cys6 (intramolecular) |
| Molecular Formula | C₄₆H₆₅N₁₃O₁₂S₂ |
| Molecular Weight | 1056.2 |
| Category | Drug Peptide Impurity / Reference Standard – lysine vasopressin (lypressin) |
| Purity | ≥98% (by HPLC); reference-standard and pharmaceutical-grade specifications available |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Acetate (per specification) |
| Disulfide Bridge | Cys1–Cys6 (intramolecular) |
| Water Content | Per specification (Karl Fischer) |
| Related Substances | Characterised per specification; named impurity / related-substance reference standards available |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg quantities (reference-standard and research); larger scale on enquiry |
| QC Documentation | COA, HPLC, MS identity; extended characterisation (related substances, peptide content) on request |
| Usage | For research and pharmaceutical analytical / quality-control use only, including as a reference standard for identity and related-substance testing. Not for human or veterinary use; not for sale to patients or individuals. Customers are responsible for regulatory and intellectual-property compliance in their territory. |
Lypressin, also known as lysine vasopressin or [Lys8]-vasopressin, is a nine-residue cyclic peptide hormone with CAS 50-57-7 and the molecular formula C46H65N13O12S2. Its one-letter sequence is CYFQNCPKG with a C-terminal amide, and it has an intramolecular disulfide bridge between the cysteine residues at positions one and six. It is the lysine-containing form of vasopressin, found in pigs and some other mammals, and we make it in-house and supply it as a synthetic lyophilized powder for research and analytical use, including as a reference standard.
Lypressin and arginine vasopressin share the same nine-residue ring and differ at only one position. Lypressin has a lysine at position eight, while arginine vasopressin has an arginine there, which changes the molecular formula and shifts the receptor profile slightly. Because the two are so similar, they are often analysed together, and each can appear as a related substance in the other's impurity profile.
Like other disulfide-containing amidated peptides, lypressin can form a defined set of related substances during synthesis and storage. Common ones include disulfide-bond isomers and the open-chain reduced form, deamidation products at the asparagine and glutamine residues, acetylated and truncated sequences, dimers, and closely related vasopressin-type sequences. These are controlled in pharmacopoeial and in-house methods, and we can prepare named impurity and related-substance reference standards alongside the parent peptide for method development and stability work.
We supply Lypressin as a synthetic peptide at high HPLC purity with a certificate of analysis, an HPLC chromatogram, and mass-spec identity confirmation. Reference-standard and pharmaceutical-grade specifications are available, including extended characterisation of related substances. Salt form, purity, and quantity can be set to your specification.
No. Lypressin supplied by SynPeptide is a raw material for research and pharmaceutical development, analysis, and manufacturing only. It is not a finished medicine, it is not for human or veterinary use, and it is not sold to patients or individuals for personal use. Any clinical or commercial medicinal use is the responsibility of an appropriately licensed party and is subject to the relevant regulatory approvals.
Lypressin (CAS 50-57-7), also called lysine vasopressin or [Lys8]-vasopressin, is the lysine form of the vasopressin antidiuretic hormone and a well-established peptide drug substance. In a peptide impurity and reference-standard programme it is the parent compound against which related substances are measured, and we supply it as a synthetic peptide for research, analytical, and quality-control use, including as a reference standard. It is not supplied as a finished medicine and not for human use.
Lypressin is a cyclic nonapeptide with the sequence H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (one-letter CYFQNCPKG-NH2), a C-terminal amide, and an intramolecular disulfide bridge between Cys1 and Cys6. Its molecular formula is C46H65N13O12S2 and its molecular weight is about 1056.2. It is the form of vasopressin that carries a lysine at position 8, found naturally in pigs and some other mammals, and it acts as an antidiuretic and vasopressor hormone like arginine vasopressin.
Lypressin differs from argipressin (arginine vasopressin) at only one position: a lysine instead of an arginine at position 8. This single change alters the molecular formula and slightly shifts the receptor profile, but the ring structure, disulfide bridge, and overall behaviour are very similar. Because the two are so close, each can appear as a related substance in the other's impurity profile, and analytical methods for vasopressin products are designed to separate them.
Regulated peptide manufacturing needs reference standards to confirm identity, calibrate assays, and run system-suitability and related-substance tests. Lypressin has a pharmacopoeial monograph and reference standard, so it is routinely controlled this way. We supply well-characterised lypressin reference material with full identity and purity data, so it can serve as the parent reference alongside named impurity standards in method development, release testing, and stability studies.
Lypressin is a small disulfide-bridged, amidated peptide, so it can form a characteristic set of related substances during synthesis, purification, and storage. Typical ones include disulfide-bond isomers and the reduced open-chain form, deamidation products, acetylated and truncated species, dimers, and closely related vasopressin-type sequences such as the arginine form. These are the species that pharmacopoeial and in-house related-substance methods are designed to separate and limit, and we can prepare named impurity and related-substance reference standards to order.
Lypressin acts through the vasopressin receptors, a family of G-protein-coupled receptors, with activity at the V1A and V2 subtypes. Through the V2 receptor in the kidney it has an antidiuretic effect by increasing water reabsorption, and through the V1A receptor it can cause vasoconstriction. This is provided as factual background; the material we supply is for research and analytical use, not for human or veterinary use, not for sale to patients, and carries no health or therapeutic claims.
Store the lyophilized peptide at -20°C, kept dry and protected from light. Because the molecule depends on its Cys1–Cys6 disulfide bridge, avoid reducing conditions and strong oxidants that could open or scramble the bond, and note that the asparagine and glutamine residues make it prone to deamidation under harsh conditions. Lypressin dissolves in water and dilute acetic acid; reconstitute in a suitable buffer, aliquot stock solutions to avoid repeated freeze-thaw, and follow the certificate of analysis for lot-specific peptide and water content.
We make Lypressin and its related-substance reference standards by solid-phase synthesis with controlled disulfide formation, and release them with a certificate of analysis, HPLC purity data, and mass-spectrometry identity confirmation, with grade and salt form set to your specification. Impurity and related-substance reference standards are prepared through our peptide modification and custom peptide synthesis services, and this product sits in our drug peptide impurities reference-standard range. Material is supplied for research and pharmaceutical analytical or manufacturing use only; customers are responsible for the regulatory and intellectual-property requirements that apply in their territory.
