| Product Name | Triptorelin Acetate |
| Synonyms | Triptorelin, Decapeptyl, Diphereline, Trelstar, [D-Trp6]-LHRH, AY-25650, BIM-21003 |
| CAS Number | 140194-24-7 (acetate); free base 57773-63-4 |
| Sequence (3-Letter) | pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH₂ |
| Sequence (1-Letter) | pGlu-HWSYwLRPG-NH₂ (w = D-Trp) |
| Molecular Formula | C₆₄H₈₂N₁₈O₁₃ (free base) |
| Molecular Weight | 1311.45 (free base); acetate salt ≈ 1371.53 |
| Category | Drug Peptide – GnRH (LHRH) Agonist |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Acetate |
| Peptide Content | ≥80% (per specification) |
| Solubility | Soluble in water |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – kg (research quantities to scale-up batches) |
| QC Documentation | COA, HPLC, MS identity (additional API/regulatory documentation on request) |
| Usage | For research and pharmaceutical development use, and as a reference standard or active pharmaceutical ingredient for manufacturing. Not for human or veterinary use; not for sale to patients. Any therapeutic use is subject to applicable regulatory approval. |
Triptorelin Acetate is the acetate salt of triptorelin, a synthetic decapeptide and gonadotropin-releasing hormone (GnRH) agonist (CAS 140194-24-7; free base 57773-63-4). Its sequence is pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2, with a D-tryptophan that makes it resistant to breakdown. It is known as a medicine under brand names such as Decapeptyl and Diphereline. We supply it as a white powder for research and pharmaceutical development.
Triptorelin is a GnRH agonist. Given continuously it first briefly stimulates the pituitary, then downregulates the GnRH receptors so the pituitary releases far less luteinising hormone (LH) and follicle-stimulating hormone (FSH). Lower LH and FSH in turn lower the body's production of sex hormones such as testosterone and estrogen. The D-tryptophan substitution gives it a longer action than natural GnRH.
Clinically, triptorelin is used in hormone-dependent conditions, including prostate cancer, endometriosis, uterine fibroids, and central precocious puberty, and in assisted-reproduction protocols. This is background information only; the material we supply is for research and pharmaceutical manufacturing use, and is not for human or veterinary use and not for sale to patients.
We supply Triptorelin Acetate with a certificate of analysis, HPLC purity data, and mass-spec identity confirmation. Additional documentation for API and regulatory work is available on request, and acetate content and purity can be set to your specification.
Yes. We manufacture Triptorelin Acetate in-house and supply from research quantities up to scale-up batches. Contact us with your required purity, salt form, and quantity for a quote.
Triptorelin Acetate is the acetate salt of triptorelin, a synthetic decapeptide and gonadotropin-releasing hormone (GnRH) agonist. It is known as a medicine under brand names such as Decapeptyl, Diphereline, and Trelstar. We supply it as a raw material for research and pharmaceutical development.
Triptorelin is a ten-amino-acid peptide with the sequence pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2. It carries a pyroglutamate at the N-terminus, a D-tryptophan at position six, and a C-terminal amide; the D-tryptophan makes it far more resistant to breakdown than natural GnRH. Its acetate-salt CAS number is 140194-24-7 (free base 57773-63-4), the free-base molecular formula is C64H82N18O13, the free-base molecular weight is about 1311, and the acetate salt is about 1372.
Triptorelin is an agonist at the GnRH receptor. When it is given continuously, it first causes a short burst of pituitary stimulation, then the GnRH receptors downregulate and the pituitary releases much less luteinising hormone (LH) and follicle-stimulating hormone (FSH). Because LH and FSH drive the gonads, their suppression lowers sex-hormone production, reducing testosterone in men and estrogen in women to low levels over a few weeks.
Triptorelin is used clinically in hormone-dependent conditions, including prostate cancer, endometriosis, uterine fibroids, and central precocious puberty, and within assisted-reproduction protocols. This information is provided as scientific and reference background only. The material supplied by SynPeptide is intended for research and pharmaceutical manufacturing, is not for human or veterinary use, and is not for sale to patients; any therapeutic use is subject to applicable regulatory approval.
We supply Triptorelin Acetate with a certificate of analysis, HPLC purity data, and mass-spectrometry identity confirmation, with further documentation available to support active pharmaceutical ingredient and regulatory work. Purity, acetate content, and salt form can be set to your specification for use as a reference standard or in process development.
We manufacture Triptorelin Acetate by solid-phase synthesis, including the pyroglutamate, the D-tryptophan residue, and the C-terminal amide, and supply it from research quantities through to scale-up batches. For related capabilities, see drug peptides, custom peptide synthesis, large-scale peptide synthesis, and peptide modification. Material is supplied for research and pharmaceutical manufacturing use only.
