| Product Name | Pentapeptide-3 (Vialox) |
| Synonyms | Vialox, Pentapeptide-3V, Gly-Pro-Arg-Pro-Ala-NH₂, Pentapeptide-3 diacetate |
| CAS Number | 135679-88-8 (diacetate salt: 725232-44-0) |
| Sequence (3-Letter) | H-Gly-Pro-Arg-Pro-Ala-NH₂ |
| Sequence (1-Letter) | GPRPA-NH₂ |
| Molecular Formula | C₂₁H₃₇N₉O₅ |
| Molecular Weight | 495.58 |
| Category | Cosmetic Peptide |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Acetate (commonly supplied as the diacetate; TFA-free) |
| Peptide Content | ≥90% |
| Solubility | Soluble in water |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – kg |
| QC Documentation | COA, HPLC, MS (included with every order) |
| Usage | For cosmetic formulation and research use only. Supplied as a raw material; finished-product efficacy and safety claims are the formulator's responsibility. Not a drug; not for direct use without formulation. |
Pentapeptide-3 is a cosmetic anti-wrinkle peptide, also sold under the trade name Vialox, with the sequence Gly-Pro-Arg-Pro-Ala (GPRPA, CAS 135679-88-8). It is a small synthetic peptide, usually supplied as the diacetate salt. It comes as a white powder for skincare and research.
It is used in anti-aging products to soften the look of expression lines and smooth skin texture, especially around the eyes and on the forehead. Suppliers describe it as relaxing the signal that drives the contraction of expression muscles. Any efficacy claim on a finished product is the formulator's responsibility.
Expression lines form when facial muscles contract. Pentapeptide-3 is reported to act at the acetylcholine receptor on muscle cells, where it competes with acetylcholine, the chemical signal that tells the muscle to contract. By limiting that signal the muscle stays more relaxed, which is the rationale for its smoothing effect on the look of expression lines. This is a cosmetic effect on the appearance of skin.
The three peptides target the same expression-line pathway by different routes. Pentapeptide-3 works at the acetylcholine receptor on the muscle side, Pentapeptide-18 works through enkephalin receptors on the nerve, and Acetyl Hexapeptide-8 (Argireline) works on the release machinery. Because the routes differ, formulators often combine them.
Yes. We manufacture Pentapeptide-3 in-house and supply from milligrams to kilograms, with COA, HPLC, and MS included. Contact us with your required purity and quantity for a quote.
Pentapeptide-3 is a synthetic peptide used in anti-aging skincare to soften the look of expression lines and smooth skin texture. It is sold under the trade name Vialox and belongs to the group of peptides that work on the signal behind facial muscle contraction.
It is a small five-amino-acid peptide with the sequence Gly-Pro-Arg-Pro-Ala (GPRPA), carrying a C-terminal amide and usually supplied as the diacetate salt. Its CAS number is 135679-88-8 (the diacetate is listed under 725232-44-0), its molecular formula is C21H37N9O5, and its molecular weight is about 495.58.
Expression lines build up where facial muscles contract again and again. Pentapeptide-3 is reported to act at the acetylcholine receptor on muscle cells, the docking site for acetylcholine, the chemical signal that tells the muscle to contract. By competing at that receptor the peptide limits the signal, so the muscle stays more relaxed. In a cosmetic product this is the rationale for using it to soften the look of expression lines and improve skin smoothness. The effect is on the appearance of the skin.
Several cosmetic peptides target expression lines, but they take different routes. Pentapeptide-3 acts on the muscle side at the acetylcholine receptor, whereas Pentapeptide-18 (Leuphasyl) works through enkephalin receptors on the nerve, and Acetyl Hexapeptide-8 (Argireline) works on the signal-release machinery. Because the mechanisms do not overlap, formulators often combine these peptides to broaden the smoothing effect on the look of dynamic lines.
Pentapeptide-3 is water-soluble and is added at low levels to leave-on serums, creams, and gels aimed at expression lines. Supplier studies report a reduction in the look of expression lines and skin roughness over about four weeks of use. As with all cosmetic actives, any claim made on the finished product is the responsibility of the formulator, and finished products should be safety-assessed for their specific formula and use.
We manufacture Pentapeptide-3 by solid-phase synthesis, including the C-terminal amide, and supply it from milligram to kilogram scale with a COA, HPLC, and MS report. For related ingredients and the underlying chemistry, see cosmetic peptides, custom peptide synthesis, and peptide modification. This material is supplied for cosmetic formulation and research use and is not a drug.
