| Target Molecule | Pentapeptide-18 (Leuphasyl) |
| Synonyms | Leuphasyl, [D-Ala²]-Leu-enkephalin, Tyr-D-Ala-Gly-Phe-Leu, H-Tyr-D-Ala-Gly-Phe-Leu-OH |
| CAS Number | 64963-01-5 |
| Sequence (3-Letter) | H-Tyr-D-Ala-Gly-Phe-Leu-OH |
| Sequence (1-Letter) | YaGFL (a = D-Ala) |
| Molecular Formula | C₂₉H₃₉N₅O₇ |
| Molecular Weight | 569.65 |
| Service Category | Custom Synthesis / Cosmetic Peptide R&D |
| Synthesis Purity | Customizable (e.g., ≥95%, ≥98%, ≥99% by HPLC) |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Acetate (TFA-free available) or Custom Options |
| Synthesis Technology | Solid-Phase Peptide Synthesis (SPPS) |
| Modification Options | N-terminal modifications, isotopic labeling, specific counter-ions |
| Available Scale | Milligram (R&D) to Kilogram (Commercial Manufacturing) |
| Analytical Data | Comprehensive COA, HPLC, MS provided per batch |
| Usage | Raw material synthesized strictly for laboratory research, cosmetic formulation R&D, and industrial manufacturing. Not a finished drug. |
Pentapeptide-18 (YaGFL, CAS 64963-01-5) is a synthetic pentamer designed with a D-alanine substitution to enhance enzymatic stability. We synthesize this specific sequence as a high-purity raw material for structural research and cosmetic formulation development.
We utilize optimized solid-phase peptide synthesis (SPPS). This platform ensures highly efficient amino acid coupling—particularly for the integrated D-alanine residue—and precise control over deletion impurities, yielding batches that meet strict HPLC purity specifications.
Yes. While the standard sequence is an enkephalin-like pentapeptide, our modification services can add targeted N-terminal protecting groups, specialized counter-ions (such as TFA to acetate conversions), or isotopic labels to suit specific physical chemistry requirements.
Our infrastructure transitions seamlessly from milligram-scale laboratory batches to kilogram-scale commercial production. We maintain rigorous batch-to-batch consistency essential for industrial-scale formulation.
We serve as a strategic technical partner. Our team assists with sequence stability testing, impurity profiling, and the provision of complete analytical documentation to accelerate downstream formulation projects.
Pentapeptide-18, defined by the sequence Tyr-D-Ala-Gly-Phe-Leu and referenced as Leuphasyl, is a stable enkephalin-like synthetic peptide. Synpeptide provides comprehensive synthetic solutions for this target molecule, leveraging our technical expertise to support industrial formulation development and cosmetic R&D.
Through our established peptide synthesis platform, we achieve efficient coupling of the pentamer sequence via optimized Solid-Phase Peptide Synthesis (SPPS). We strictly control impurity profiles and sequence deletions during manufacturing, ensuring the final Pentapeptide-18 material meets exact purity specifications (routinely ≥98% via HPLC). This rigorous process control guarantees the batch-to-batch reproducibility required for both early-stage research and late-stage commercial formulation.
The standard structure of Pentapeptide-18 features a D-alanine substitution for enzymatic stability. Beyond this baseline, we offer extensive peptide modification services. Formulators can request specific counter-ion exchanges, targeted N-terminal modifications for altered solubility, or isotopic labeling for tracking studies. These structural adjustments enable researchers to precisely tune the molecule's physical properties for advanced delivery systems.
Scaling a peptide from benchtop research to commercial application demands stable manufacturing protocols. We facilitate efficient large-scale peptide synthesis for Pentapeptide-18, managing the transition from milligram screening batches to kilogram-scale production. Our large-scale infrastructure ensures a continuous, reliable supply chain for global cosmetic manufacturers, supported by complete analytical documentation including COA, MS, and HPLC data for every delivered batch.
We function as a technical extension of our clients' teams, providing one-stop peptide formulation support. Our engineers assist clients in stability testing, degradation profiling, and identifying optimal handling conditions for Pentapeptide-18 in various matrices. By delivering precise analytical data alongside high-purity synthetic capacity, we enable R&D teams to execute complex formulation projects efficiently and confidently.
