| Product Name | Glucagon Hydrochloride |
| Synonyms | Glucagon HCl, Glucagon (1-29) (human) hydrochloride, GlucaGen |
| CAS Number | 11140-85-5 (hydrochloride); free-base peptide 16941-32-5 |
| Sequence (3-Letter) | H-His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH |
| Sequence (1-Letter) | HSQGTFTSDYSKYLDSRRAQDFVQWLMNT |
| Molecular Formula | C₁₅₃H₂₂₆ClN₄₃O₄₉S (hydrochloride); free-base peptide C₁₅₃H₂₂₅N₄₃O₄₉S |
| Molecular Weight | 3519.2 (hydrochloride); 3482.75 (free-base peptide) |
| Category | Drug Peptide – Glucagon Receptor Agonist |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white powder |
| Counter Ion | Chloride (hydrochloride salt; other salt forms available on request) |
| Peptide Content | ≥80% (per specification) |
| Solubility | Soluble in water as the hydrochloride and in dilute acid; limited solubility in neutral water and prone to aggregation |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – kg (research quantities to scale-up batches) |
| QC Documentation | COA, HPLC, MS identity (additional API/regulatory documentation on request) |
| Usage | For research and pharmaceutical development use, and as a reference standard or active pharmaceutical ingredient for manufacturing. Not for human or veterinary use; not for sale to patients. Any therapeutic use is subject to applicable regulatory approval. |
Glucagon Hydrochloride is the hydrochloride salt of glucagon, a 29-amino-acid peptide hormone made by the pancreas (CAS 11140-85-5; free-base peptide 16941-32-5). Its sequence is HSQGTFTSDYSKYLDSRRAQDFVQWLMNT, a single linear chain with no chemical modifications. The hydrochloride form dissolves more easily in water than the free peptide. We supply it as a white powder for research and pharmaceutical development.
Glucagon works mainly in the liver, where it activates the glucagon receptor. This drives the breakdown of stored glycogen into glucose and the making of new glucose, which raises blood sugar. Glucagon is the counter-regulatory partner to insulin: insulin lowers blood sugar, glucagon raises it. It also relaxes the smooth muscle of the gut.
Clinically, glucagon is used to treat severe low blood sugar, for example in people with insulin-treated diabetes, and as an aid in imaging of the digestive tract because it relaxes the gut muscle. This is background information only; the material we supply is for research and pharmaceutical manufacturing use, and is not for human or veterinary use and not for sale to patients.
We supply Glucagon Hydrochloride with a certificate of analysis, HPLC purity data, and mass-spec identity confirmation. Additional documentation for API and regulatory work is available on request, and salt form and purity can be set to your specification.
Yes. We manufacture Glucagon Hydrochloride in-house and supply from research quantities up to scale-up batches. Contact us with your required purity, salt form, and quantity for a quote.
Glucagon Hydrochloride is the hydrochloride salt of glucagon, a 29-amino-acid peptide hormone made by the pancreas that raises blood sugar. It is the counter-regulatory partner to insulin and is known as a medicine under brand names such as GlucaGen. We supply it as a raw material for research and pharmaceutical development.
Glucagon is a single linear chain of 29 amino acids with the sequence HSQGTFTSDYSKYLDSRRAQDFVQWLMNT and no chemical modifications. Its sequence is the same across most mammals, including humans. Supplied as the hydrochloride, it dissolves in water more readily than the free peptide. Its hydrochloride CAS number is 11140-85-5 (free-base peptide 16941-32-5), the hydrochloride molecular formula is C153H226ClN43O49S, the hydrochloride molecular weight is about 3519, and the free-base peptide is about 3483.
Glucagon acts mainly on the liver, where it binds the glucagon receptor (GCGR). Through that receptor it stimulates the breakdown of stored glycogen into glucose and the synthesis of new glucose, raising the level of sugar in the blood. This is the opposite of insulin, which lowers blood sugar; the balance between the two hormones is central to glucose control. Glucagon also relaxes the smooth muscle of the gastrointestinal tract.
Glucagon is used clinically to treat severe low blood sugar, for example in people with insulin-treated diabetes, and as an aid during imaging of the digestive tract, where relaxing the gut muscle improves the view. This information is provided as scientific and reference background only. The material supplied by SynPeptide is intended for research and pharmaceutical manufacturing, is not for human or veterinary use, and is not for sale to patients; any therapeutic use is subject to applicable regulatory approval.
We supply Glucagon Hydrochloride with a certificate of analysis, HPLC purity data, and mass-spectrometry identity confirmation, with further documentation available to support active pharmaceutical ingredient and regulatory work. Because glucagon tends to aggregate, careful handling and formulation matter; purity, salt form, and counter-ion can be set to your specification for use as a reference standard or in process development.
We manufacture Glucagon Hydrochloride by solid-phase synthesis and supply it from research quantities through to scale-up batches. For related capabilities, see drug peptides, custom peptide synthesis, large-scale peptide synthesis, and our peptide CDMO services. Material is supplied for research and pharmaceutical manufacturing use only.
