| Product Name | Carbetocin |
| Synonyms | Duratocin, Pabal, Lonactene, Depotocin, d(COMOT), [2-O-methyltyrosine]-deamino-1-carba-oxytocin |
| CAS Number | 37025-55-1 (free base); acetate salts 1631754-28-3, 1936459-26-5 |
| Sequence (3-Letter) | But-Tyr(Me)-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH₂ (cyclic But1–Cys6 thioether) |
| Sequence (1-Letter) | But-Y(Me)IQNCPLG-NH₂ (thioether bridge But1–Cys6) |
| Molecular Formula | C₄₅H₆₉N₁₁O₁₂S |
| Molecular Weight | 988.16 |
| Category | Drug Peptide – Oxytocin Analog (Uterotonic) |
| Purity | ≥98% (by HPLC) |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Acetate (TFA-free available; salt form per specification) |
| Peptide Content | ≥80% (per specification) |
| Solubility | Soluble in water |
| Storage | -20°C, desiccated, protected from light |
| Available Scale | mg – kg (research quantities to scale-up batches) |
| QC Documentation | COA, HPLC, MS identity (additional API/regulatory documentation on request) |
| Usage | For research and pharmaceutical development use, and as a reference standard or active pharmaceutical ingredient for manufacturing. Not for human or veterinary use; not for sale to patients. Any therapeutic use is subject to applicable regulatory approval. |
Carbetocin is a synthetic, long-acting analog of the hormone oxytocin (CAS 37025-55-1; acetate salt also available). Chemically it is a carba-analog of oxytocin, with the sequence But-Tyr(Me)-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 closed by a thioether bridge: the ring disulfide of oxytocin is replaced by a more stable carba link, the N-terminus is deaminated, and the tyrosine is O-methylated. We supply it as a white powder for research and pharmaceutical development.
Carbetocin is an oxytocin-receptor agonist. Like oxytocin it binds the oxytocin receptor and makes the uterus contract, and it acts on the receptors that drive milk let-down. Its structural changes make it resist the enzymes that quickly clear oxytocin, so it lasts longer, and it is selective for the oxytocin receptor over the vasopressin V2 receptor.
Clinically, carbetocin is used as a uterotonic to prevent uterine atony and postpartum bleeding, particularly after cesarean delivery. This is background information only; the material we supply is for research and pharmaceutical manufacturing use, and is not for human or veterinary use and not for sale to patients.
We supply Carbetocin with a certificate of analysis, HPLC purity data, and mass-spec identity confirmation. Additional documentation for API and regulatory work is available on request, and salt form and purity can be set to your specification.
Yes. We manufacture Carbetocin in-house and supply from research quantities up to scale-up batches. Contact us with your required purity, salt form, and quantity for a quote.
Carbetocin is a synthetic, long-acting analog of the hormone oxytocin, used as a uterotonic. It is known as a medicine under brand names such as Duratocin and Pabal. We supply it as a raw material for research and pharmaceutical development.
Carbetocin is a carba-analog of oxytocin with the sequence But-Tyr(Me)-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2, closed by a thioether bridge. It differs from oxytocin in three ways: the disulfide that closes the oxytocin ring is replaced by a more stable carba (thioether) link, the N-terminus is deaminated, and the position-two tyrosine is O-methylated. These changes make it much more stable than oxytocin. Its free-base CAS number is 37025-55-1 (acetate salts 1631754-28-3 and 1936459-26-5), its molecular formula is C45H69N11O12S, and its molecular weight is about 988.
Carbetocin is an agonist at the oxytocin receptor. Like the natural hormone, it binds that receptor and triggers contraction of the uterus, and it acts on the oxytocin receptors of the breast that drive milk let-down. Because its structure resists the enzymes that quickly break down oxytocin, it acts for much longer, and it is selective for the oxytocin receptor over the vasopressin V2 receptor.
Carbetocin is used clinically as a uterotonic to prevent uterine atony and postpartum bleeding, particularly after cesarean delivery, where its long action removes the need for a prolonged infusion. This information is provided as scientific and reference background only. The material supplied by SynPeptide is intended for research and pharmaceutical manufacturing, is not for human or veterinary use, and is not for sale to patients; any therapeutic use is subject to applicable regulatory approval.
We supply Carbetocin with a certificate of analysis, HPLC purity data, and mass-spectrometry identity confirmation, with further documentation available to support active pharmaceutical ingredient and regulatory work. Purity, salt form, and counter-ion can be set to your specification for use as a reference standard or in process development.
We manufacture Carbetocin by solid-phase synthesis, including the deaminated, O-methylated modifications and the thioether ring closure, and supply it from research quantities through to scale-up batches. For related capabilities, see drug peptides, custom peptide synthesis, peptide modification, and cyclic peptides. Material is supplied for research and pharmaceutical manufacturing use only.
