| Target Molecule | Acetyl Tetrapeptide-5 (Eyeseryl) |
| Synonyms | Eyeseryl, Ac-βAla-His-Ser-His, N-Acetyl-β-alanyl-L-histidyl-L-seryl-L-histidine |
| CAS Number | 820959-17-9 |
| Sequence (3-Letter) | Ac-βAla-His-Ser-His-OH |
| Sequence (1-Letter) | Ac-βAla-HSH-OH |
| Molecular Formula | C₂₀H₂₈N₈O₇ |
| Molecular Weight | 492.5 |
| Service Category | Custom Synthesis / Cosmetic Peptide R&D |
| Synthesis Purity | Customizable (e.g., ≥95%, ≥98%, ≥99% by HPLC) |
| Appearance | White to off-white lyophilized powder |
| Counter Ion | Free acid / acetate (TFA-free available) or Custom Options |
| Synthesis Technology | Solid-Phase Peptide Synthesis (SPPS) |
| Modification Options | Isotopic labeling, specific counter-ions, alternate N-terminal protections |
| Available Scale | Milligram (R&D) to Kilogram (Commercial Manufacturing) |
| Analytical Data | Comprehensive COA, HPLC, MS provided per batch |
| Usage | Raw material synthesized strictly for laboratory research, cosmetic formulation R&D, and industrial manufacturing. Not a finished drug. |
Acetyl Tetrapeptide-5 (Ac-βAla-HSH, CAS 820959-17-9) is a synthetic tetrapeptide featuring an N-terminal acetyl group and incorporating beta-alanine. We synthesize this specific sequence as a high-purity raw material for structural research and cosmetic formulation development.
We utilize optimized solid-phase peptide synthesis (SPPS). This platform ensures highly efficient amino acid coupling—managing the specific steric requirements of beta-alanine—and precise control over deletion impurities, yielding batches that meet strict HPLC purity specifications.
Yes. While the standard structure requires N-terminal acetylation, our modification services can add targeted isotopic labels, specific counter-ions (such as TFA to acetate conversions), or alternate terminal protections to suit varying physical chemistry requirements for advanced R&D.
Our infrastructure transitions seamlessly from milligram-scale laboratory batches to kilogram-scale commercial production. We maintain rigorous batch-to-batch consistency essential for industrial-scale cosmetic formulation.
We serve as a strategic technical partner. Our team assists with sequence stability testing, impurity profiling, and the provision of complete analytical documentation to accelerate downstream formulation projects.
Acetyl Tetrapeptide-5, defined by the sequence Ac-βAla-His-Ser-His and referenced as Eyeseryl, is a synthetic tetramer widely utilized in cosmetic formulation. Synpeptide provides comprehensive synthetic solutions for this target molecule, leveraging our technical expertise to support industrial formulation development and cosmetic R&D.
Through our established peptide synthesis platform, we achieve efficient coupling of the tetrapeptide sequence via optimized Solid-Phase Peptide Synthesis (SPPS). We strictly control impurity profiles during the integration of beta-alanine and subsequent residues, ensuring the final Acetyl Tetrapeptide-5 material meets exact purity specifications (routinely ≥98% via HPLC). This rigorous process control guarantees the batch-to-batch reproducibility required for both early-stage research and late-stage commercial formulation.
The standard structure of Acetyl Tetrapeptide-5 requires N-terminal acetylation. Beyond this baseline, we offer extensive peptide modification services. Formulators can request specific counter-ion exchanges to adjust solubility profiles, targeted isotopic labeling for tracking studies, or alternate terminal modifications. These structural adjustments enable researchers to precisely tune the molecule's physical properties for advanced delivery systems.
Scaling a peptide from benchtop research to commercial application demands stable manufacturing protocols. We facilitate efficient large-scale peptide synthesis for Acetyl Tetrapeptide-5, managing the transition from milligram screening batches to kilogram-scale production. Our large-scale infrastructure ensures a continuous, reliable supply chain for global cosmetic manufacturers, supported by complete analytical documentation including COA, MS, and HPLC data for every delivered batch.
We function as a technical extension of our clients' teams, providing one-stop peptide formulation support. Our engineers assist clients in stability testing, degradation profiling, and identifying optimal handling conditions for Acetyl Tetrapeptide-5 in various matrices. By delivering precise analytical data alongside high-purity synthetic capacity, we enable R&D teams to execute complex formulation projects efficiently and confidently.
